Product
0102
Spermidine Trihydrochloride (3HCl) Powder
Products Description
Spermidine Trihydrochloride Powder is a water-soluble, high-purity form of spermidine - an essential polyamine compound that promotes autophagy, cell renewal, and healthy aging. The active ingredient, spermidine, is a naturally occurring polyamine found in all living cells. It plays a key role in cellular metabolism and has received widespread attention for its ability to stimulate autophagy, a self-cleaning process that helps remove damaged cells and supports cell regeneration. As a salt form, spermidine has increased stability and solubility, making it ideal for dietary supplements, anti-aging formulations, and scientific research.
In today's health and wellness landscape, demand for spermidine-based ingredients - especially stable forms like spermidine trihydrochloride - is growing rapidly. However, high-quality sources remain limited due to the complexity of the purification process and the need for consistent bioactivity.
Botanical Cube Inc. specializes in producing spermidine trihydrochloride powder with a purity of ≥98% using a proprietary fermentation and purification process. Compared to many common synthetic products, our powders have cleaner properties, better batch consistency, and proven solubility, making them more suitable for water-based formulations and clinical applications.
Why choose our Spermidine trihydrochloride powder?
1. High purity
Our product purity can reach ≥99.5% purity, thanks to our fermentation production and multi-stage crystallization. This method can reduce residual biogenic amines and improve batch stability, which is critical for pharmaceutical grade or high-end supplement applications.
2. High quality
In addition to HPLC, we also validate each batch for heavy metals, microbial limit testing (TAMC/TYMC) and residual solvent analysis according to ICH Q3C guidelines to ensure full compliance with European and North American regulatory requirements.
3. Good water solubility and no odor
Our powder is completely soluble in water at room temperature (dissolution time is less than 30 seconds at a concentration of 10 mg/mL) and has no noticeable amine odor.
COA
| ITEM | SPECIFICATION | RESULT | TEST METHOD |
| Identification | Positive | Complies | In-house |
| Appearance | White to off-white powder | Complies | Visual inspection |
| Odor | Characteristic, non-offensive | Complies | Organoleptic |
| Assay (on dry basis) | ≥99.0% | 99.53% | HPLC |
| Loss on Drying | ≤1.0% | 0.21% | USP <731> |
| pH (1% aqueous solution) | 4.5 – 6.5 | 5.3 | USP <791> |
| Residue on Ignition | ≤0.5% | 0.08% | USP <281> |
| Heavy Metals | ≤10 ppm | <5 ppm | ICP-MS |
| Lead (Pb) | ≤1 ppm | <0.1 ppm | ICP-MS |
| Arsenic (As) | ≤1 ppm | <0.1 ppm | ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | <0.01 ppm | ICP-MS |
| Cadmium (Cd) | ≤1 ppm | <0.1 ppm | ICP-MS |
| Total Plate Count | ≤1,000 CFU/g | <100 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g | USP <61> |
| E. coli | Negative / 10g | Negative | USP <62> |
| Salmonella | Negative / 25g | Negative | USP <62> |
| Solubility | Soluble in water | Complies | In-house |
| Particle Size (D90) | 80–120 mesh | 100 mesh | Sieve analysis |
What is spermidine trihydrochloride used for?
1. Dietary Supplements
Used in anti-aging capsules, longevity formulas, and NAD+ boosters.
Often used in combination with polyphenols or vitamin B complex.
2. Cosmeceuticals
Used in anti-aging creams and serums for its cell regeneration potential.
Helps reduce oxidative stress in skin cells.
3. Cell Research
Applied in life science research related to autophagy, aging, and mitochondrial function.
4. Functional Foods
Formulated into nutraceuticals, energy drinks, or sachets for daily longevity support.
Recommended Usage & Dosage
| Application | Typical Dosage (Daily) |
| Dietary Supplement | 1–10 mg/day (pure compound basis) |
| Functional Beverage | 2–5 mg per serving |
| Skin Topical Formulation | 0.05–0.5% concentration (w/w) |
| Cell Research Use | As per experimental design |
Tips: Always consult with a formulation specialist or regulatory expert when creating consumer-facing products.
Frequently Asked Questions (FAQ)
1. Are spermidine and spermidine trihydrochloride the same?
Not exactly. Spermidine is the active polyamine molecule, while spermidine trihydrochloride is its stable salt form, which is ideal for formulation and transportation due to its better solubility and shelf stability.
2. How should spermidine trihydrochloride be stored?
Store in a sealed container in a cool (≤25°C), dry place away from direct sunlight and moisture.
3. Is spermidine safe?
Yes, as long as the dose is appropriate. Human clinical trial reports show that doses up to 10 mg/day also have good safety. However, the safety of the final product depends on the formulation and regulatory compliance.
4. How is spermidine absorbed?
Spermidine is absorbed in the small intestine via polyamine transporters and can cross the blood-brain barrier in small amounts, making it suitable for cognitive support applications.