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Phellodendron bark extract Berberine HCL Powder
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Phellodendron bark extract Berberine HCL Powder

CAS No.:  633-65-8
Specification: Berberine HCL ≥ 97%
Appearance: Yellow crystalline powder
Test Method: HPLC
Solubility: Soluble in water and ethanol
Applications: Dietary Supplements, Blood Sugar Support Capsules,Skincare Actives
Package: 1-25kg or customized
Sample: Sample available
Storage: Cool dry place away from direct sunlight
Certificates: ISO22000, FSSC22000, Halal, cGMP, Organic
Not for private sale

    Products Description

    Berberine HCl powder from Phellodendron amurense bark extract is a highly purified botanical ingredient standardized to 97% or higher. Extracted from the bark of the Phellodendron amurense tree, our berberine HCl powder is a fine yellow crystalline powder with excellent water solubility, making it ideal for use in dietary supplements, blood sugar support formulations, and herbal health products. Berberine HCl has anti-inflammatory, antimicrobial, and metabolic modulatory properties that have been validated in numerous clinical and preclinical studies.
    With the growing global interest in natural metabolic support, berberine HCl has become one of the most sought-after botanical active ingredients, especially in North America and Europe, where demand for blood sugar management and weight control supplements is growing.
    The uniqueness of our berberine HCl product lies in our proprietary fermentation-free extraction process, which consistently yields a high purity product (≥97%) while maintaining ultra-low heavy metal content—<1.0 ppm for lead and <0.5 ppm for arsenic—well below industry standards.

    Why choose our Phellodendron Bark Extract Berberine HCL Powder?

    1. High Active Content – ≥97% Berberine HCL
    We standardize our product to ≥97% purity, tested by HPLC.Lot-to-lot variation is tightly controlled within ±1%, ensuring formulation accuracy for capsules, tablets, or sachets.
    2. 100% Botanical Source – No Fermentation or Synthetics
    Our Berberine HCL is extracted exclusively from wild-harvested Phellodendron bark.No GMO materials, synthetic fermentation residues, or artificial fillers—meets clean-label and natural origin standards.
    3. Clean Extraction – No Harsh Solvents
    Extraction uses only ethanol and purified water, without methanol or acetone.Fully compliant with EU food-grade standards and preferred by nutraceutical brands focused on safety.
    4.Low Heavy Metals
    Our Berberine HCL Powder consistently tests below 1.0 ppm lead, 0.5 ppm arsenic, and 0.5 ppm cadmium (ICP-MS), exceeding pharmacopeia safety standards and minimizing formulation risks.
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    Phellodendron bark extract Berberine HCL Powder 2

    COA           

    Item Specification Result
    Product Name Phellodendron Bark Extract Berberine HCL Powder Complies
    Appearance Yellow crystalline powder Complies
    Odor & Taste Characteristic Complies
    Assay (Berberine HCL) ≥97.0% (HPLC) 97.42%
    Loss on Drying ≤2.0% 0.89%
    Ash ≤1.0% 0.42%
    Bulk Density 0.45–0.75 g/mL 0.59 g/mL
    Tapped Density 0.60–0.90 g/mL 0.78 g/mL
    Solubility Soluble in water & ethanol Complies
    Particle Size 95% pass 80 mesh Complies
    Heavy Metals ≤10 ppm Complies
    Lead (Pb) ≤1.0 ppm (ICP-MS) 0.41 ppm
    Arsenic (As) ≤1.0 ppm (ICP-MS) 0.28 ppm
    Cadmium (Cd) ≤1.0 ppm (ICP-MS) 0.17 ppm
    Mercury (Hg) ≤0.1 ppm (ICP-MS) Not detected
    Total Plate Count ≤1,000 CFU/g <100 CFU/g
    Yeast & Mold ≤100 CFU/g <10 CFU/g
    E. coli Negative Negative
    Salmonella Negative Negative
    Staphylococcus aureus Negative Negative

    What is the application of berberine?

    1. Dietary Supplements
    Widely used in capsule and tablet formats for general wellness and metabolic support.
    2. Blood Sugar Support Formulas
    Incorporated into formulas targeting insulin sensitivity and glucose regulation.
    3. Weight Management Products
    Commonly found in fat metabolism and appetite control blends.
    4. Gut Health Solutions
    Supports microbiome balance and helps reduce inflammation in the digestive tract.
    5. Traditional Herbal Blends
    Used in combination with other Eastern herbs like Coptis and Scutellaria.
    6. Skin Health Capsules
    Employed for its anti-inflammatory and antibacterial properties, especially in acne-targeted products.
    7. Pet Health Additives
    Added to animal supplements for antimicrobial and gut-supportive functions.

    Recommended Usage & Dosage

    1.Capsules/Tablets: 
    500–1500 mg per day, divided into 2–3 doses
    2.Functional Blends: 
    0.5–2% inclusion rate depending on formulation goals
    3.Topical Formulations:
    Not commonly used due to low dermal absorption, but 0.1–0.5% may be explored under clinical supervision
    Note: Usage should align with local regulatory guidelines (e.g., EFSA, FDA, etc.)

    Frequently Asked Questions (FAQ)

    1. Can it be combined with Metformin or other medications?
    Many use Berberine as a natural Metformin alternative. However, co-usage should be done under medical guidance due to potential additive effects on blood sugar.
    2. Is Berberine natural or synthetic?
    Our Berberine HCL is 100% natural, extracted from Phellodendron amurense bark through a water-alcohol process — not synthetically manufactured.
    3. What makes high-purity Berberine better?
    Standardized purity (≥97%) ensures consistent dosing, higher bioavailability, and fewer unwanted alkaloid contaminants — critical for formulator trust and product stability.

    Trusted Supplier of Berberine HCL Powder Bulk and OEM Orders

    As a reliable supplier of Phellodendron Bark Extract Berberine HCL Powder, we offer bulk orders and custom solutions. Our product meets high-quality standards, ensuring consistency and safety for your business.For inquiries or orders, contact us at info@btncbio.com

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