Pyrroloquinoline Quinone (PQQ) Powder
Naturally fermented, high-purity PQQ disodium salt (Methoxatin) optimized for cell energy and cognitive health formulations. Perfect for combining with Coenzyme Q10 to trigger synergistic mitochondrial biogenesis.
The Science of Mitochondrial Synergy: PQQ & CoQ10
Why combining these two cellular powerhouses is the gold standard for energy, cardiovascular longevity, and cognitive formulas.
Mitochondria are the primary energy generators in human cells, responsible for producing adenosine triphosphate (ATP), the chemical currency of life. As we age, mitochondrial efficiency declines, leading to cellular fatigue, cognitive slowing, and cardiovascular vulnerabilities. Science-driven nutraceutical brands are increasingly looking beyond single-ingredient solutions, focusing instead on biological synergy. The pairing of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 (CoQ10) represents the pinnacle of this approach.
While both compounds support energy production, they operate via entirely distinct, complementary mechanisms. Coenzyme Q10 acts as an essential electron shuttle within the inner mitochondrial membrane, facilitating the transport of electrons through the Electron Transport Chain (ETC) to synthesize ATP. Without adequate CoQ10, cellular respiration slows down, and oxidative damage increases.
Conversely, PQQ (Methoxatin) acts as a powerful redox cofactor that addresses the root cause of mitochondrial decline: quantity and structural integrity. PQQ triggers the activation of the PGC-1α pathway, a master regulator that stimulates mitochondrial biogenesis—the birth of entirely new, healthy mitochondria within aging cells. Furthermore, PQQ is an exceptionally robust antioxidant, capable of undergoing tens of thousands of catalytic cycles without breaking down, protecting newly formed mitochondria from oxidative damage.
ATP Generation
CoQ10 optimizes the Electron Transport Chain, ensuring efficient conversion of nutrients into cellular ATP energy.
Mitochondrial Biogenesis
PQQ activates key transcription factors (CREB, PGC-1α) to stimulate the growth of new mitochondria in cells.
Redox Protection
PQQ provides 5,000 times the antioxidant capacity of Vitamin C, shielding cells from mitochondrial decay.
Enhanced Cardiovascular and Cognitive Performance
The heart and the brain consume more energy than almost any other organs in the human body. Clinical research demonstrates that when PQQ and CoQ10 are administered together, they yield superior cognitive outcomes—such as improved short-term memory, attention span, and processing speed—compared to either ingredient taken alone.
For cardiovascular formulations, this combination supports myocardial energy output, helping maintain healthy blood pressure and endothelial function. By offering both ingredients in bulk, Botanical Cube Inc. enables supplement manufacturers to purchase premium, compatible grades of both PQQ and CoQ10, streamlining sourcing and ensuring consistent blending quality.
Recommended Commercial Blending Ratios
Optimizing automated encapsulation and tableting with standardized, clinically supported ratios.
The Classic Cardioprotective & Energy Stack
For automated encapsulation and clean-label dietary supplements, the industry standard pairing relies on a precise weight ratio. Formulators typically combine 20mg of PQQ Disodium Salt with 100mg to 200mg of bulk Coenzyme Q10.
Because PQQ is highly potent at low dosages, achieving uniform distribution in a powder blend requires high-flowability raw materials. Our micronized PQQ powder (D90 < 10μm) blends seamlessly with both Ubiquinone and Ubiquinol forms of CoQ10, eliminating segregation issues during high-speed capsule filling.
Advanced Formulation Stacks for B2B Wholesale
Expand your product line by combining our PQQ and CoQ10 with other high-demand active monomers. We support multi-ingredient wholesale and custom blending.
The Longevity Stack
PQQ + CoQ10 + NMN
Targeting cellular aging, NAD+ replenishment, and mitochondrial revitalization in a single premium capsule.
The Brain & Focus Nootropic
PQQ + CoQ10 + Alpha-GPC
Formulated to support acetylcholine synthesis, NGF (Nerve Growth Factor) activity, and mental clarity.
Sports & Cellular Recovery
PQQ + CoQ10 + L-Carnitine
Accelerating fatty acid transport to the mitochondria for immediate fuel utilization and muscle recovery.
Certificate of Analysis (COA)
Rigorous lab testing and compliance standards for every batch of PQQ Disodium Salt Powder.
| Test Item | Specification | Result | Method |
|---|---|---|---|
| Appearance | Reddish-brown fine powder | Conforms | Visual |
| Purity (HPLC) | ≥99.0% | 99.3% | HPLC |
| Loss on Drying | ≤1.0% | 0.45% | USP <731> |
| Residue on Ignition | ≤0.5% | 0.2% | USP <281> |
| Particle Size (D90) | <10μm | 7.8μm | Laser Diffraction |
| Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
| Lead (Pb) | ≤0.1 ppm | 0.08 ppm | ICP-MS |
| Arsenic (As) | ≤0.1 ppm | 0.05 ppm | ICP-MS |
| Cadmium (Cd) | ≤0.1 ppm | 0.03 ppm | ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | 0.02 ppm | ICP-MS |
| Total Plate Count | ≤1,000 cfu/g | 300 cfu/g | USP <61> |
| Yeast & Mold | ≤100 cfu/g | 10 cfu/g | USP <61> |
| E. coli | Negative | Negative | USP <62> |
| Salmonella | Negative | Negative | USP <62> |
| Solvent Residues | <500 ppm | 120 ppm | GC-MS |
| Assay Conclusion | Conforms | Conforms | QC Approved |
Advanced Manufacturing Process
How our naturally fermented, low-temperature vacuum dried PQQ is produced for maximum bioactivity.
At Botanical Cube Inc., we prioritize biological activity over cheap synthetic shortcuts. Our PQQ disodium salt is manufactured utilizing 100% natural microbial fermentation. This process yields a cleaner, more bioavailable compound that aligns perfectly with clean-label and organic brand positioning.
To protect the delicate quinone ring structure of PQQ from thermal degradation, our processing facility utilizes low-temperature vacuum drying (<60°C). This guarantees minimal water absorption, prevents oxidation during processing, and results in a highly stable, consistent particle size (D90 < 10μm) that dissolves effortlessly in aqueous solutions.
Manufacturing Process Flowchart
Quality Assurance & R&D Integrity
"Quality is at the core of everything we do."
Quality Highlights
✔ 3 Independent R&D Centers
✔ GMP-Compliant Manufacturing
✔ Third-Party Verified Testing
✔ Full Batch Traceability
Global Certifications
✔ ISO 9001 & ISO 22000
✔ FDA Facility Registration
✔ HALAL & KOSHER Certified
✔ USDA Organic & cGMP Compliant
Testing Partners
✔ SGS Laboratories
✔ Eurofins Scientific
✔ Pony Testing Group
✔ Mérieux NutriSciences
Botanical Lab & R&D Core Focus
Herbal Utilization
Development of traditional herbs.
Product Innovation
Research of new botanical products.
Customized Service
Formulation based customized production.
Natural Extracts
Applications of natural plant extracts.
Lab Test Phase
We use advanced analytical methods, including HPLC, TLC, UV, and AAS, to accurately identify plant species and parts, ensuring each sample meets regulatory standards. A dedicated account manager oversees each R&D project to fully address customer needs.
Workshop Trial
Qualified lab samples proceed to pilot testing in the workshop. Through exploration and research, we've developed customized pilot projects that meet our technical and quality standards while maintaining high production efficiency.
Pilot-scale Workshop
The most important link in the process from R&D to production. Provide reliable data for further production, and further revise the production process in the test, eliminate the parts that are not suitable for industry, and then develop a process suitable for production.
Our Growth & History
Relying on our parent company Tianben Bio, we have continuously expanded our capabilities since 2008 to provide top-tier raw materials globally.
Parent Company Tianben Bio was Founded, commencing botanical extraction operations.
Our dedicated R&D Center was established to specialize in monomer isolation and purification.
Sanyuan Factory was founded in Xi'an, significantly increasing extraction output.
Comprehensive Quality Management System established, aligning with global USP standards.
Obtained HALAL, KOSHER, and ISO certifications, opening doors to international markets.
Began showcasing our active ingredients at Vitafoods Europe and SupplySide West.
B.C.I. Bio Company (Botanical Cube Inc.) was founded to lead global B2B operations.
Shanyang Factory was established, specializing in high-purity chemical intermediates.
Huxian Factory was founded, adding 50,000 sqm of advanced extraction space.
Obtained multiple national patents and High-Tech Enterprise Certification.
Obtained cGMP and NOP USDA Organic certifications for premium ingredient lines.
Our Manufacturing Facilities
Spanning over 200 acres with an annual raw material processing capacity exceeding 5,000 tons.
Sanyuan Factory
Established in 2012 in Sanyuan City, Xi'an, Sanyuan Factory represents our foundation in scaled plant extraction.
Over the past decade, Sanyuan Factory has refined its manufacturing workflows, investing heavily in technology, operator training, and rigorous quality control protocols to ensure consistent batch-to-batch outcomes.
Shanyang Factory
Established in 2019 in Shanyang County, Shangluo City, this facility covers more than 3,000 square meters.
Focusing on the isolation of natural active monomers and chemical intermediates, this factory employs state-of-the-art chromatography systems and ultrafiltration units to guarantee high-purity outputs like our 98% PQQ disodium salt.
Huxian Factory
Our flagship facility, Huxian Factory, was established in 2021 at the foot of the Qinling Mountains, spanning over 50,000 square meters.
It features a 4,000-square-meter extraction workshop equipped with advanced vacuum concentrators and extraction towers, alongside a 2,000-square-meter refining area. Huxian Factory plays a critical role in our B2B supply chain, processing over 3,000 tons of raw materials annually.
Company Culture & Values
Committed to advancing human health through integrity, innovation, and reliable raw material supply chains.
Our Mission
Fight tirelessly for the cause of human health!
Our Vision
To become the global most trusted manufacturer of natural ingredients.
Our Values
Integrity, Responsibility, Cooperation, Commitment, Innovation, Dedication!
Business Philosophy
Quality comes first, honesty is the foundation!
Exhibition Style
Frequently Asked Questions (FAQ)
Answers to common formulate and technical questions regarding PQQ and CoQ10.
PQQ Bulk Supplier & OEM Factory
Partner with a direct manufacturer to elevate your anti-aging and skincare formulations. We provide high-purity PQQ powder available for bulk wholesale and custom OEM projects, ensuring your brand stays competitive in the beauty and longevity markets. Our facility holds comprehensive international certifications, guaranteeing that every batch meets global safety and quality standards.
The core advantage of choosing our PQQ lies in its superior bioactivity and reliable supply chain, giving your products a distinct edge in cellular health and skin rejuvenation. Whether you are developing a new daily chemical line or expanding a supplement brand, we have the scale and expertise to support your growth. Reach out today to discuss your specifications or request a sample.
Email Us: info@btncbio.com
